原著論文

- 2019年


Shi L, Kuhnell D, Borra VJ, Langevin SM, Nakamura T, Esfandiari L. “Rapid and label-free isolation of small extracellular vesicles from biofluids utilizing a novel insulator based dielectrophoretic device”, Lab Chip, 2019 Nov 7;19(21):3726-3734


Salem ESB, Vonberg AD, Borra VJ, Gill RK, Nakamura T. “RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases”, Front Cardiovasc Med, 2019 Aug 20;6:106


Kim D, Brocker CN, Takahashi S, Yagai T, Kim T, Xie G, Wang H, Qu A, Gonzalez FJ. “Keratin 23 Is a Peroxisome Proliferator-Activated Receptor Alpha-Dependent, MYC-Amplified Oncogene That Promotes Hepatocyte Proliferation”, Hepatology, 2019 Jul;70(1):154-167


Xie G, Yin S, Zhang Z, Qi D, Wang X, Kim D, Yagai T, Brocker CN, Wang Y, Gonzalez FJ, Wang H, Qu A. “Hepatocyte Peroxisome Proliferator-Activated Receptor α Enhances Liver Regeneration after Partial Hepatectomy in Mice”, Am J Pathol, 2019 Feb;189(2):272-282


- 2018年


Kim A, Shah AS, Nakamura T. “Extracellular Vesicles: A Potential Novel Regulator of Obesity and Its Associated Complications”, Children (Basal), 2018 Nov 15;5(11)


Salem ESB, Murakami K, Takahashi T, Bernhard E, Borra V, Bethi M, Nakamura T. “Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method”, J Vis Exp, 2018 Oct 23;(140)


Zhang C, Seo J, Murakami K, Salem ESB, Bernhard E, Borra VJ, Choi K, Yuan CL, Chan CC, Chen X, Huang T, Weirauch MT, Divanovic S, Qi NR, Thomas HE, Mercer CA, Siomi H, Nakamura T. “Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology”, Nat Commun, 2018 Sep 10;9(1):3658


Peng J, Li Y, Wang X, Deng S, Holland J, Yates E, Chen J, Gu H, Essandoh K, Mu X, Wang B, McNamara RK, Peng T, Jegga AG, Liu T, Nakamura T, Huang K, Perez-Tilve D, Fan GC. “An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPARγ Ubiquitination”, Cell Rep, 2018 Jun 19;23(12):3607-3620


Yamazaki T, Li W, Yang L, Li P, Cao H, Motegi SI, Udey MC, Bernhard E, Nakamura T, Mukouyama YS. “Whole-Mount Adult Ear Skin Imaging Reveals Defective Neuro-Vascular Branching Morphogenesis in Obese and Type 2 Diabetic Mouse Models”, Sci Rep, 2018 Jan 11;8(1):430


Takahashi S, Tanaka N, Fukami T, Xie C, Yagai T, Kim D, Velenosi TJ, Yan T, Krausz KW, Levi M, Gonzalez FJ. “Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development”, Hepatol Commun, 2018 Oct 1;2(12):1567-1582


Yan T, Wang H, Cao L, Wang Q, Takahashi S, Yagai T, Li G, Krausz KW, Wang G, Gonzalez FJ, Hao H. “Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation”, Drug Metab Dispos, 2018 Sep;46(9):1310-1319


Zhang Y, Yan T, Sun D, Xie C, Zheng Y, Zhang L, Yagai T, Krausz KW, Bisson WH, Yang X, Gonzalez FJ. “Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis”, Drug Metab Dispos, 2018 Jul;46(7):1030-1040


- 2017年


Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Shah YM, Wu Y, Jiang C, Gonzalez FJ. “Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis”, Nat Med, 2017 Nov;23(11):1298-1308


Yagai T, Matsui S, Harada K, Inagaki FF, Saijou E, Miura Y, Nakanuma Y, Miyajima A, Tanaka M. “Expression and localization of sterile alpha motif domain containing 5 is associated with cell type and malignancy of biliary tree”, PLoS One, 2017 Apr 7;12(4):e0175355


- 2016年


Gao X, Xie C, Wang Y, Luo Y, Yagai T, Sun D, Qin X, Krausz KW, Gonzalez FJ. “The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4”, Biochem Pharmacol, 2016 Nov 1;119:93-104


Yan T, Wang H, Zhao M, Yagai T, Chai Y, Krausz KW, Xie C, Cheng X, Zhang J, Che Y, Li F, Wu Y, Brocker CN, Gonzalez FJ, Wang G, Hao H. “Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis”, Drug Metab Dispos, 2016 May;44(5):720-31


- 2015年


Youssef OA, Safran SA, Nakamura T, Nix DA, Hotamisligil GS, Bass BL. “Potential role for snoRNAs in PKR activation during metabolic stress”, Proc Natl Acad Sci U S A, 2015 Apr 21;112(16):5023-8


Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamisligil GS. “A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity”, Cell Rep, 2015 Apr 14;11(2):295-307


- 2014年


Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GS. “Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice”, Diabetes, 2014 Feb;63(2):526-34


Yagai T, Miyajima A, Tanaka M. “Semaphorin 3E secreted by damaged hepatocytes regulates the sinusoidal regeneration and liver fibrosis during liver regeneration”, Am J Pathol, 2014 Aug;184(8):2250-9


- 2013年以前(Selected)


Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ. “Novel role of PKR in inflammasome activation and HMGB1 release”, Nature, 2012 Aug 30;488(7413):670-4


Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS. “Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis”, Cell, 2010 Feb 5;140(3):338-48


Nakamura T, Yao R, Ogawa T, Suzuki T, Ito C, Tsunekawa N, Inoue K, Ajima R, Miyasaka T, Yoshida Y, Ogura A, Toshimori K, Noce T, Yamamoto T, Noda T. “Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta”, Nat Genet, 2004 May;36(5):528-33


Yoshida Y*, Nakamura T*, Komoda M, Satoh H, Suzuki T, Tsuzuku JK, Miyasaka T, Yoshida EH, Umemori H, Kunisaki RK, Tani K, Ishii S, Mori S, Suganuma M, Noda T, Yamamoto T. “Mice lacking a transcriptional corepressor Tob are predisposed to cancer”, Genes Dev, 2003 May 15;17(10):1201-6

*Equal Contribution

Nakamura T. “The Role of dsRNA pathways in inflammation and cancer in obesity” Journal of Clinical and Experimental Medicine. 2016 Jun; 257 (12): 1245-1250 (Review in Japanese).

Nakamura T. “dsRNA in immunometabolism” Oncotarget. 2015 Aug; 6 (24): 19940-19941, PubMed ID: 26343371 (Review).

Nakamura T. “Molecular mechanism of double-stranded RNA pathway-mediated immunometabolic regulation” BIO Clinica: Lipid metabolism and signaling. 2015 Aug; 30 (9): 838-842 (Review in Japanese).

Nakamura T. “Role of double-stranded RNA pathways in immune-metabolic regulation” BIO Clinica Special Edition: Chronic inflammation in endocrinology and metabolism. 2015 Feb; 4 (1): 104-108 (Review in Japanese).

Nakamura T. “Molecular basis of chronic inflammatory responses and metabolic diseases in obesity” Experimental Medicine. 2014 Feb; 32 (3): 380-385 (Review in Japanese).

Nakamura T. “Revisiting Metformin” Science Translation Medicine. 5 (172), p172ec31, 2013 (Commentary).

Nakamura T. “Microbes and Type 1 Diabetes” Science Translation Medicine. 5 (168), p168ec14, 2013 (Commentary).

Nakamura T. “Resveratrol: Too Early to Bring Out the Wine?” Science Translation Medicine. 4 (164), p164ec228, 2012 (Commentary).

Nakamura T. “Weighty Considerations” Science Translation Medicine. 4 (160), p160ec209, 2012 (Commentary).

Nakamura T. “A Warning Bell Tolls for Type 1 Diabetes” Science Translation Medicine. 4 (156), p156ec189, 2012 (Commentary).

Nakamura T. “Microbial Manipulation of Metabolism” Science Translation Medicine. 4 (148), p148ec153, 2012 (Commentary).

Nakamura T. “Mitochondrial Workout” Science Translation Medicine. 4 (144), p144ec134, 2012 (Commentary).

Nakamura T. “You Are What and When You Eat” Science Translation Medicine. 4 (141), p141ec116, 2012 (Commentary).

Nakamura T. “Perceiving Your Appetite” Science Translation Medicine. 4 (136), p136ec97, 2012 (Commentary).

Nakamura T. “Bypassing Alzheimer’s Diseases” Science Translation Medicine. 4 (132), p132ec79, 2012 (Commentary).

Nakamura T. “Bypassing Alzheimer’s Diseases” Science Translation Medicine. 4 (132), p132ec79, 2012 (Commentary).

Nakamura T. “Diseases of Resistance” Science Translation Medicine. 4 (128), p128ec60, 2012 (Commentary).

Nakamura T. “What’s Up with BAT?” Science Translation Medicine. 4 (125), p125ec45, 2012 (Commentary).

Nakamura T and Hotamisligil GS. “Impact of qualitative alterations of lipid on metabolism in obesity” Experimental Medicine. 2012 Feb; 30 (3): 435-440 (Review in Japanese) 

Nakamura T and Hotamisligil GS. “Obesity, ER stress, and metabolic disease” Experimental Medicine. 2009 Mar; 27 (4): 498-504 (Review in Japanese).

総説・著書・解説

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